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Home / Antibodies

SMAD1/2/3/5 Antibody (R30395)

SKU : BHA17104075

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NSJ Bioreagents

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Mfr.No.	R30395
Clonality	Polyclonal
Description	SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human SMAD1/2/3/5 (GPLQWLDKVLTQMGS) was used as the immunogen for this SMAD1/2/3/5 antibody (100% homologous human, mouse and rat).
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No

Antigen	SMAD1/2/3/5
Uniprot	Q15797

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the SMAD 1/2/3/5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Western blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104075	R30395	100 ug	$419		Add to Cart

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