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Home / Antibodies

SOD1 Antibody / Superoxide Dismutase 1 (V3869SAF)

SKU : BHA17125690

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NSJ Bioreagents

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Mfr.No.	V3869SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Full length recombinant human protein was used as the immunogen for the SOD1 antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	Optimal dilution of the SOD1 antibody should be determined by the researcher.

Uniprot	P00441

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the SOD1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	ELISA
Description	ELISA: 1-5ug/ml for coating (order BSA/sodium azide-free format)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17125690	V3869SAF-100UG	100 ug	$499		Add to Cart

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