The ALAS1 gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate.
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human ALAS1 was used as the immunogen for the ALAS1 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
ALAS1
Uniprot
P13196
Clone No
EOA-1
Format
Purified
Purification
Affinity purified
Storage
Store the ALAS1 antibody at -20°C.
Applications
IF/ICC, WB
Dilution
Western blot: 1:500-1:2000,Immunofluorescence/Immunocytochemistry: 1:50-1:200