The protein encoded by the IRF1 gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. (RefSeq)
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human Interferon regulatory factor 1 was used as the immunogen for the IRF1 antibody.
Isotype
IgG
Predicted Reactivity
Human, Rat
Reactivity
Human, Rat
Recombinant
No
Subcellular Location
Nuclear, cytoplasmic
Antigen
IRF1
Uniprot
P10914
Clone No
DHE-9
Format
Purified
Purification
Affinity purified
Storage
Store the IRF1 antibody at -20°C.
Applications
IHC-P, WB
Dilution
Western blot: 1:500-1:1000,Immunohistochemistry (FFPE): 1:50-1:100