The KRT8 gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. (RefSeq)
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human Cytokeratin 8 / KRT8 was used as the immunogen for the Keratin 8 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
KRT8
Uniprot
P05787
Clone No
CIG-11
Format
Purified
Purification
Affinity purified
Storage
Store the Keratin 8 antibody at -20°C.
Applications
IHC-P, WB
Dilution
Western blot: 1:10000-1:20000,Immunohistochemistry (FFPE): 1:50-1:200