The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. (RefSeq)
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human Ku70 / XRCC6 was used as the immunogen for the Ku70 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Subcellular Location
Nuclear
Antigen
Ku70
Uniprot
P12956
Clone No
AAIG-24
Format
Purified
Purification
Affinity purified
Storage
Store the Ku70 antibody at -20°C.
Applications
IHC-P, WB
Dilution
Western blot: 1:500-1:2000,Immunohistochemistry (FFPE): 1:50-1:200