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Home / Primary Antibodies / Monoclonal Antibodies

Phospho-Histone H2AX Antibody (pS139)

SKU : BHA17109314

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NSJ Bioreagents

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Mfr.No.	RQ4503
Clonality	Monoclonal
Description	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. (UniProt)
Formulation	Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host	Rabbit
Immunogen Region	The amino acids surrounding a phosphorylated serine at position 139 were used as the immunogen for the phospho-Histone H2AX antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse
Reactivity	Human, Mouse
Recombinant	Yes
Subcellular Location	Nucleus

Antigen	Histone H2AX
Uniprot	P16104
Clone No	AbH41

Format	Purified
Purification	Protein A affinity
Storage	After reconstitution, the phospho-Histone H2AX antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, IHC-P
Dilution	Western blot: 1:500-1:1000ug/ml,IHC (FFPE): 1:50-1:200,IF/ICC: 1:50-1:200

Product Manual	Data Sheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA17109314	RQ4503	100ul	$439		Add to Cart

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